The edited T-cells are then multiplied in the lab before being administered to patients. He says this makes it a game-changer “in the small niche in which it is being licensed and used”. In CAR-T treatments, doctors extract T-cells from patients' blood, genetically engineering them in the lab to make them specifically identify and target cancer cells. T-Cell Discovery Could Herald Universal Cancer Immunotherapy An international research team has found a new type of T-cell that could lead to cell immunotherapies able to treat cancers beyond the reach of current CAR T-cell therapies. The first-approved living drugs, chimeric antigen receptor (CAR) T-cell therapies have shown unprecedented efficacy against several hematologic malignancies. Professor Andrew Sewell with Research Fellow Garry Dolton Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy. “CAR T-cell therapy is going to spread,” says Carl June, MD. CAR T cells are “the first truly personalised therapy, because the cells come from the patient,” says Professor Karl Peggs, a Cancer Research UK-funded immunotherapy expert.
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